Primary Polyomavirus Infection, Not Reactivation, as the Cause of Trichodysplasia Spinulosa in Immunocompromised Patients

Classic human polyomaviruses (JC and BK viruses) become pathogenic when reactivating from latency. For the rare skin disease trichodysplasia spinulosa, we show that manifestations of the causative polyomavirus (TSPyV) occur during primary infection of the immunosuppressed host. High TSPyV loads in blood and cerebrospinal fluid, sometimes coinciding with cerebral lesions and neuroendocrine symptoms, marked the acute phase of trichodysplasia spinulosa, whereas initiation and maturation of TSPyV seroresponses occurred in the convalescent phase. TSPyV genomes lacked the rearrangements typical for reactivating polyomaviruses. These findings demonstrate the clinical importance of primary infection with this rapidly expanding group of human viruses and explain the rarity of some novel polyomavirus-associated diseases.Peer reviewe

SS-duality in Vafa-Witten theory for non-simply laced gauge groups

Vafa-Witten theory is a twisted N=4 supersymmetric gauge theory whose partition functions are the generating functions of the Euler number of instanton moduli spaces. In this paper, we recall quantum gauge theory with discrete electric and magnetic fluxes and review the main results of Vafa-Witten theory when the gauge group is simply laced. Based on the transformations of theta functions and their appearance in the blow-up formulae, we propose explicit transformations of the partition functions under the Hecke group when the gauge group is non-simply laced. We provide various evidences and consistency checks.Comment: 14 page